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KMID : 0882420200950030201
Korean Journal of Medicine
2020 Volume.95 No. 3 p.201 ~ p.204
Successful Treatment of Acquired Perforating Dermatosis in a Peritoneal Dialysis Patient Using Oral Isotretinoin
Kim Hui-Seo

Lee Sang-Hee
Lee Mi-Ji
Jue Mihn-Sook
Lee Dong-Young
Moon Kyoung-Hyub
Kim Beom
Abstract
Acquired perforating dermatosis (APD) triggers severe itching, and is observed most often in patients with diabetes mellitus (DM) and chronic kidney disease (CKD). Various treatments, such as topical steroids, topical and oral retinoids, allopurinol, and ultraviolet B (UVB) phototherapy, have been used. However, as the precise etiology is unknown, there are a lack of well-established treatment guidelines. We report a peritoneal dialysis patient with a diagnosis of APD who was resistant to topical steroids, phototherapy, allopurinol, and topical retinoids. Severe pruritus persisted, which compromised his ability to lead a normal life. As a final treatment option, we used oral isotretinoin and the patient experienced a dramatic improvement.
KEYWORD
Chronic kidney disease peritoneal dialysis, Isotretinoin, Pruritus
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